Debut and breakthrough
Qureshi was initially scheduled to make her film debut with
Billa II, a
Tamil gangster-thriller, directed and produced by
Chakri Toleti, after surviving an audition out of 700 candidates. Although cast as the female lead, when the film was delayed, Qureshi left the project to honour other work commitments.
 When asked whether she had any regrets, she said: "I have no regrets. I wish it had worked out, but it didn't. I am not someone who sits and laments over things. I was approached for several other south films too, but the roles weren't what I was looking for".
Qureshi made her feature film debut with a supporting role in
Anurag Kashyap's critically acclaimed
two-part crime drama
Gangs of Wasseypur – Part 1 (2012), where Qureshi was cast as the supportive wife of a criminal (played by
Nawazuddin Siddiqui). She described her character as a small-town airhead who thinks she is the prettiest girl in the village: "Mohsina tries to copy everything she sees on the big screen in her own little ways. She is heavily influenced by
 The film premiered at the
65th Cannes Film Festival, and both the film and Qureshi received positive reviews from critics.
Govind Nihalani noted her screen presence, comparing the actress to
Smita Patil: "an earthiness, sincerity, intensity and warmth of personality, qualities that distinguished Smita, apart from the fact that she was a very fine and instinctive actress. Huma is a good enough actress on her own, someone who can stand apart from the crowd and hold her own".
Taran Adarsh of
Bollywood Hungama noted: "Huma Qureshi, who's introduced much later in the film...is wonderful".
The Express Tribune added: "When it comes to looks, [Huma] is different from the typical Bollywood actors".
 In 2012, Qureshi was ranked third, the highest female position, on
Rediff.com's annual list of "Bollywood's Top Ten Debutants" (male and female).
 Following the success of the first part, she reprised her role of Mohsina in the
second instalment of the
Gangs of Wasseypur series,
Gangs of Wasseypur – Part 2. The film premiered in the
Directors' Fortnight at the Cannes Film Festival with its prequel. It opened to wide critical acclaim,
 and her portrayal again received positive reviews. Madhureeta Mukherjee of
The Times of India said: "Huma Qureshi, with her gaudy clothes, designer sun-glasses and unusual attractiveness is the hottest cheez in Wasseypur. She beautifully lends support as a powerful man's 'prouder' better-half, even in his worst crimes",
 and Taran Adarsh found her "simply fantastic".
 Both films earned her Best Female Debut and Best Supporting Actress nominations at several award ceremonies (including the
 Qureshi described Gangs of Wasseypur as a "life-changing film".
That same year, Qureshi completed her three-film contract with Anurag Kashyap Films by starring in
Luv Shuv Tey Chicken Khurana, a romantic comedy, which describes a quest for an ancient family dish; Chicken Khurana. Directed by
Sameer Sharma, she played the role of a feisty
Punjabi girl, Harman (star
Kunal Kapoor's love interest). The film was a financial success, and Rediff.com noted that "Huma Qureshi looks right for the role and she delivers a wonderful performance".
 Aniruddha Guha of the
Daily News and Analysis said: "[Qureshi], on the other hand, is charming as the fiery Punjaban, Harman. Her refreshingly natural acting style impresses again in a role that has shades of her character in Gangs of Wasseypur". However,
Anupama Chopra found her performance to be "a little bland".
Further works (2013–17)
Huma Qureshi at Zee Cine Awards 2013.
For her next feature, Qureshi was cast as a
witch in the supernatural thriller
Ek Thi Daayan (2013), alongside
Konkona Sen Sharma and
Kalki Koechlin. Dealing with the themes of
witchcraft, the film was based on 'Mobius Trips', a short story written by
Konkona Sen Sharma's father.
 It received mixed reviews from critics,
 but proved to be a profitable venture at the box office.
 Qureshi's performance was also well received.
The Indian Express said: "Qureshi has just a few good moments, but makes the most of them", while
Koimoi noted that "Qureshi has a remarkably pleasant and confident screen presence".
Raja Sen particularly praised the female cast and wrote "The three leading ladies are smashing in their roles...Each plays their given role with frighteningly good flair, and each deserves a big hand."
 After appearing in Ek Thi Daayan, Qureshi, along with
R. Madhavan hosted the
60th ceremony of the
National Film Awards, an event presented by the
Directorate of Film Festivals to honor the Best Films of the year (then 2012) in the
Indian cinema by the
President of India. The ceremony was held on May 3, 2013 at the
Vigyan Bhavan during the presidency of
Shortly afterwards, Qureshi played the titular character in the short movie Sujata—released as one of the segments of
anthology film by Anurag Kashyap. She played the eponymous lead as a young girl who is struggling to come out of the clutches of her tormenting cousin brother (played by
 The film was screened at
Indian Film Festival of Los Angeles before its release and received generally positive reviews, and Qureshi's performance was critically acclaimed and earned her a
Special Mention Award at the ceremony.
 Her subsequent release that year included the underworld drama
D-Day, in which she was featured as Zoya Rehman, an explosive R.A.W agent with an
ensemble cast including
Rishi Kapoor and
Shruti Hassan. During the script narration, the director
Nikhil Advani offered Qureshi the choice of which woman to play, either Suraiya (later played by Hassan) or Zoya; she decided on Zoya to expand her horizons as an actress.
 The film was a flop at the box office and received mixed feedback from critics, while Qureshi's performance received favourable reviews;
Subhash K. Jha mentioned that Qureshi's acting is "effortlessly appealing and effective."
In 2014, Qureshi featured in
Abhishek Chaubey's black comedy
Dedh Ishqiya (2014), a sequel to the 2010 film
Arshad Warsi and
Naseeruddin Shah .
 Dedh Ishqiya was a commercial success, earning ₹270 million (US$4.1 million) in India and abroad and Qureshi received praise for her portrayal of the promiscuous companion of a
con woman (played by Dixit).
 In a 5-star review, Raja Sen commented that "Qureshi uses her fiercely intelligent eyes to great effect", whilst Mohar Basu agreed, saying that "Huma Qureshi is brilliant and confident. The actress has in her the vivacious energy that proves her talent."
 Qureshi's last appearance of 2014 was Rochak Kohli's music video "Mitti Di Khusboo" with
India Today noted: "The chemistry the two Ayushmann and Huma share onscreen has the raw flavor of the countryside romance".
The following year, Qureshi appeared as a prostitute in
Sriram Raghavan's crime thriller
Varun Dhawan and Nawazuddin Siddiqui.
 Raja Sen praised her acting and wrote that she "is hauntingly good as a call-girl". The film was a commercial success, and Qureshi received the Filmfare Best Supporting Actress nomination.
Highway marked her debut in Marathi cinema. It received mixed reviews from critics, and proved to be a moderate box office success.
 The same year, she acted in the collaborative film
X: Past Is Present. It was directed by a team of eleven filmmakers with Qureshi appearing in "Knot", a segment directed by film critic Raja Sen, where she appeared alongside
2016 marked the debut of Qureshi in
Malayalam cinema with
White. She starred in dual roles in the film alongside
Mammootty. The film opened to generally negative reviews from critics.
Qureshi's first release of 2017 was the courtroom comedy drama
Jolly LLB 2, where she appeared alongside
Akshay Kumar. A sequel to the 2013 film
Jolly LLB, the film received mixed reviews from critics and was a box office success.
 Her next film was
Gurinder Chadha's British-Indian historical drama
Viceroy's House. The film follows the story of
Viceroy's House in 1947 during the
partition of India and was screened at the
67th Berlin International Film Festival.
 She then appeared along with her brother Saqib Saleem in
Prawaal Raman's horror film
Dobaara: See Your Evil (2017), a remake of
Mike Flanagan's Hollywood flick
Oculus. Flanagan also served as the executive producer of the film.
As of July 2017, Huma is filming for the Tamil language film