Upon Henry's death, he was succeeded by his son Edward VI. Since Edward was then only nine years old, he could not rule directly. Instead, Henry's will designated 16 executors to serve on a council of regency until Edward reached the age of 18. The executors chose Edward Seymour, 1st Earl of Hertford, Jane Seymour's elder brother, to be Lord Protector of the Realm. If Edward died childless, the throne was to pass to Mary, Henry VIII's daughter by Catherine of Aragon, and her heirs. If Mary's issue failed, the crown was to go to Elizabeth, Henry's daughter by Anne Boleyn, and her heirs. Finally, if Elizabeth's line became extinct, the crown was to be inherited by the descendants of Henry VIII's deceased younger sister, Mary, the Greys. The descendants of Henry's sister Margaret – the Stuarts, rulers of Scotland – were thereby excluded from the succession. This final provision failed when James VI of Scotland became King of England in 1603.