During their long and complex history on the North American continent, Indigenous peoples of the Northeastern Woodlands vigorously adopted every imaginable effort to survive and thrive. However, "By 1690, may (sic) of the Native American peoples in the eastern part of the region had been driven out by the Iroquois and their allies."
European Colonial Powers increasingly weakened Native sovereignty and decimated their populations. In 1763, the Pope and European royals divided North America into four main zones for the British, the French the Spanish, and all the rest.
The invading settlers of the Ohio, mostly escaping lives of poverty, and persecution, had just won their freedom from the British. They had purchased or been awarded title to the land, and they naturally fought to protect their outposts in this 'New World.'
The Northwest Indian War began after the American Revolution, and those living near frontier outposts north of the Ohio were particularly subject to attack.