Hoxie Simmons, a Rogue River Indian, c. 1870.
The interaction of the Rogue River Indians and the first European-American settlers traveling through the area was relatively peaceful. However, the situation changed drastically with the opening of the
Oregon Trail and the
gold rushes in northern
California and later in eastern Oregon. Larger groups of settlers and miners entered the area, consuming without restrictions the natural resources upon which the Indians relied on for survival, competing for game and fish, and chopping down entire forests of oak trees.
The first recorded hostilities were caused by the American
Ewing Young’s travel to Oregon in 1834. His party murdered several natives and buried their bodies on the island where the party was camped.
 These bodies were later discovered by the local tribe. They retaliated the next year, attacking an American fur trapping party that passed through.
 Four of the eight European-Americans were killed;
William J. Bailey and
George Gay were two survivors.
In 1837 (as part of the
Willamette Cattle Company) Bailey, Gay and others were herding cattle north to the
Willamette Valley when Gay shot and killed a native boy. He was shot in revenge for earlier attacks against whites.
 The local Indians raided the cattle drive but killed or drove off only a few cattle.
Peter Skene Ogden encountered inland Rogue River natives in 1827.
The first known contact between these groups of Indians and Europeans occurred when British explorer
George Vancouver anchored off
Cape Blanco, about 30 miles (48 km) north of the mouth of the Rogue River, and Indians visited the ship in canoes.
 In 1826,
Alexander Roderick McLeod of the
Hudson's Bay Company (HBC) led an overland expedition from HBC's regional headquarters in
Fort Vancouver to as far south as the Rogue.
In 1827 an HBC expedition led by
Peter Skene Ogden made the first direct contact between whites and the inland Rogue River natives when he crossed the Siskiyou Mountains to look for beaver for the fur trade.
 Friction between Indians and whites was relatively minor during these early encounters. But in 1834 an HBC expedition led by
Michel Laframboise was reported to have killed 11 Rogue River natives, and shortly thereafter a party led by an American trapper,
Ewing Young, shot and killed at least two more.
The name Rogue River was apparently derived from French fur trappers, who called the river La Riviere aux Coquins, because they regarded the natives as rogues (coquins).
The number of whites entering the Rogue River watershed greatly increased after 1846, when a party of 15 men led by
Jesse Applegate developed a southern alternative to the
Oregon Trail; the new trail was used by emigrants headed for the Willamette Valley.
 Later called the
Applegate Trail, it passed through the Rogue and Bear Creek valleys and crossed the Cascade Range between present-day Ashland and south of Upper Klamath Lake.
 From 90 to 100 wagons and 450 to 500 emigrants used the new trail later in 1846, passing through Rogue Indian homelands between the headwaters of Bear Creek and the future site of Grants Pass and crossing the Rogue about 4.5 miles (7.2 km) downstream of it.
 Despite fears on both sides, violence in the watershed in the 1830s and 1840s was limited; "Indians seemed interested in speeding whites on their way, and whites were happy to get through the region without being attacked."
In 1847, the
Whitman massacre and the
Cayuse War in what became southeastern
Washington raised fears among white settlers throughout the region. They formed large volunteer
militias to fight Indians.
 Tensions intensified among whites passing through the Rogue River Valley in 1848 at the start of the
California Gold Rush, when hundreds of men from the
Oregon Territory passed through the Rogue Valley on their way to the
Sacramento River basin.
 After Indians attacked a group of miners returning along the Rogue in 1850, former territorial governor
Joseph Lane negotiated a peace treaty with Apserkahar, a leader of the
Takelma Indians. It promised protection of Indian rights and safe passage through the Rogue Valley for white miners and settlers.
Mining in the Rogue River valley
Joel Palmer, Oregon Superintendent of Indian Affairs
prospecting for gold in the watershed, including a Bear Creek tributary called Jackson Creek, where they established a mining camp in 1851 at the site of what later became Jacksonville.
 Indian attacks on miners that year led to
U.S. Army intervention and fighting near
Table Rock between Indians and the combined forces of professional soldiers and volunteer miner militias.
John P. Gaines, the new territorial governor, negotiated a new treaty with some but not all of the Indian bands, removing them from Bear Creek and other tributaries on the south side of the main stem.
 At about the same time, more white emigrants, including families with women and children, were settling in the region. By 1852, about 28
donation land claims had been filed in the Rogue Valley.
Further clashes in 1853 led to the
Treaty with the Rogue River that established the
Table Rock Indian Reservation across the river from the federal Fort Lane.
 As the white population increased and Indian losses of land, food sources, and personal safety mounted, bouts of violence upstream and down continued through 1854–1855.
In 1855 this friction culminated in open conflict, which lasted into 1856, and is now called the Rogue River War.
 The Guide to the Cayuse, Yakima, and Rogue River Wars Papers 1847–1858 at the
University of Oregon summarizes the war as follows:
Throughout the 1850s
Governor Stevens of the Washington Territory clashed with the U.S. Army over Indian policy: Stevens wanted to displace Indians and take their land, but the army opposed land grabs. White settlers in the Rogue River area began to attack Indian villages, and Captain Smith, commandant of
Fort Lane, often interposed his men between the Indians and the settlers. In October 1855, he took Indian women and children into the fort for their own safety; but a mob of settlers raided their village, killing 27 Indians. The Indians killed 27 settlers expecting to settle the score, but the settlers continued to attack Indian camps through the winter. On May 27, 1856, Captain Smith arranged the surrender of the Indians to the US Army, but the Indians attacked the soldiers instead. The commander fought the Indians until reinforcements arrived the next day; the Indians retreated. A month later they surrendered and were sent to reservations.
Suffering from cold, hunger, and disease on the Table Rock Reservation, a group of Takelma returned to their old village at the mouth of
Little Butte Creek in October 1855. After a volunteer militia attacked them, killing 23 men, women, and children, they fled downriver, attacking whites from Gold Hill to Galice Creek.
 Confronted by volunteers and regular army troops, the Indians at first repulsed them; however, after nearly 200 volunteers launched an all-day assault on the remaining natives, the war ended at Big Bend (at RM 35 or RK 56) on the lower river.
 By then, fighting had also ended near the coast, where, before retreating upstream, a separate group of natives had killed about 30 whites and burned their cabins near what later became Gold Beach.
Most of the Rogue River Indians were removed in 1856 to reservations further north. About 1,400 were sent to the
Coast Reservation in central Oregon, later renamed the
 They were placed with other Indians who were from
Coastal Salish tribes, such as the Tillamook, the Siletz, and the Clatsop. To protect 400 natives still in danger of attack at Table Rock,
Joel Palmer, the
Oregon Superintendent of Indian Affairs, ordered their removal to the newly established
Grande Ronde Reservation in
Yamhill County, Oregon.
Battle of Hungry Hill
The Battle of Hungry Hill, the largest battle of the Rogue River Wars,
 occurred on Oct. 31, 1855. Two hundred Native Americans, located in the mountains southwest of present-day
 and armed with
muzzleloaders and bows and arrows, managed to hold off a group of "more than 300 ... dragoons, militiamen and volunteers".
The Native Americans were camped with their women and children
 on the top of a hill, with the soldiers located across a narrow ravine about 1,500 feet deep. The U.S. troops had planned a surprise attack, but their position was given away by a warming fire. Seeing that they had been discovered, the soldiers attempted to charge down the ravine and up the other side, but were thwarted, as the Native Americans had good cover in the high ground, and many proved to be good marksmen. "U.S. troops and militiamen retreated out of the mountains ... As many as 36 were dead, missing or severely wounded. Native casualties numbered fewer than 20."
In 2012, the location of the Battle of Hungry Hill was discovered by archeologists from
Southern Oregon University's Laboratory of Anthropology.
Mark Tveskov, who discovered the site using metal detectors, states that although this battle involving 500 people was a "major defeat" for U.S. troops, it is not well known. He attributes this in part to "the disappointment and blame among militiamen and Army regulars over the defeat. Back then, Oregon telegraph cables were in their infancy, and photographers who would document the Civil War several years later were not on hand. If Hungry Hill had happened after the Civil War, it would have been front-page news in the New York Times."