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Science is the methodical study of nature including testable explanations and predictions. From classical antiquity through the 19th century, science as a type of knowledge was more closely linked to philosophy than it is now and, in fact, in the Western world, the term "natural philosophy" encompassed fields of study that are today associated with science, such as astronomy, medicine, and physics. However, during the Islamic Golden Age foundations for the scientific method were laid by Ibn al-Haytham in his Book of Optics. While the classification of the material world by the ancient Indians and Greeks into air, earth, fire and water was more philosophical, medieval Middle Easterns used practical, experimental observation to classify materials.

Today, the ever-evolving term "science" refers to the pursuit of knowledge, not the knowledge itself. It is often synonymous with "natural and physical science" and often restricted to those branches of study relating to the phenomena of the material universe and their laws. Although the term implies exclusion of pure mathematics, many university faculties include Mathematics Departments within their Faculty of Science. The dominant sense in ordinary use has a narrower use for the term "science." It developed as a part of science becoming a distinct enterprise of defining the "laws of nature"; early examples include Kepler's laws, Galileo's laws, and Newton's laws of motion. In this period it became more common to refer to natural philosophy as "natural science." Over the course of the 19th century, the word "science" became increasingly associated with the disciplined study of the natural world, including physics, chemistry, geology and biology. This sometimes left the study of human thought and society in a linguistic limbo, which was resolved by classifying these areas of academic study as social science. For example, psychology evolved from philosophy, and has grown into an area of study.

Currently, there are both "hard" (e.g. biological psychology) and "soft" science (e.g. social psychology) fields within the discipline. As a result, and as is consistent with the unfolding of the study of knowledge and development of methods to establish facts, each area of psychology employs a scientific method. Reflecting the evolution of the development of knowledge and established facts and the use of the scientific method, Psychology Departments in universities are found within: Faculty of Arts and Science, Faculty of Arts, and a Faculty of Science. Similarly, several other major areas of disciplined study and knowledge exist today under the general rubric of "science", such as formal science and applied science.

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DNA damage resulting in multiple broken chromosomes
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. Consequently, the DNA repair process must be constantly active so it can respond rapidly to any damage in the DNA structure.

The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred by its DNA, can enter one of three possible states: an irreversible state of dormancy, known as senescence; cell suicide, also known as apoptosis or programmed cell death; or unregulated cell division, which can lead to the formation of a tumor that is cancerous.

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Moon Dedal crater.jpg
Credit: Apollo 11 Crew, NASA

The far side of the Moon as photographed by the crew of Apollo 11. The largest crater pictured is the Daedalus crater.

Selected biography

Frank Macfarlane Burnet at the Walter and Eliza Hall Institute, 1945
Sir Frank Macfarlane Burnet (3 September 1899 – 31 August 1985) was an Australian virologist best known for his contributions to immunology. He went on to conduct pioneering research on bacteriophages and viruses at the Walter and Eliza Hall Institute, and served as director of the Institute from 1944 to 1956. His virology research resulted in significant discoveries concerning their nature and replication and their interaction with the immune system.

From the mid-1950s, he worked extensively in immunology and was a major contributor to the theory of clonal selection, which explains how lymphocytes target antigens for destruction. Burnet and Peter Medawar were co-recipients of the 1960 Nobel Prize in Physiology or Medicine for demonstrating acquired immune tolerance. This research provided the experimental basis for inducing immune tolerance, the platform for developing methods of transplanting solid organs.

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