Son of a lawyer, and nephew of a doctor, Picard refused to follow the careers of law and medicine, and dedicated himself to the theater encouraged by his friend François Andrieux. He first became an actor before producing his first play, Le Badinage dangereux, in 1789.
Picard worked with the Comédiens-Italiens. In 1807 Picard was received by Bernardin de Saint-Pierre when he was elected to the Académie française. Before he became the head of the Odéon-Théâtre in 1816, he directed the Académie Impériale de Musique. He was at Odéon-Théâtre until 1821.
In the painting Louis-Benoît Picard and his family, Pauline Auzou depicts Picard with his wife Victoria Longchamps (far right), his brother and sisters Latour and Adele Picard and Mrs. Guersant. With Mrs. Guersant is her husband physician Louis Benoit Guersant, their son, Paul Benedict Guersant Louis, who became a doctor, and baby daughter who became Ms. Blache. LaTour's wife wore a red shawl over a black dress. The Picard's father, who had been a lawyer and parliamentarian, is represented in a portrait made by Auzou, which won a medal of honor at the 1806 Paris Salon. His writing desk holds his manuscripts and a book he is reading.