Liv Kristine was born in Stavanger, and joined the Norwegian gothic metal band Theatre of Tragedy in 1994 as a backup singer, but was soon sharing lead vocals duties with Raymond István Rohonyi. She was fired from Theatre of Tragedy in 2003, a fact she learned about through the band's website. She had been living in Germany since 1996 and collaborating with the death metal band Atrocity, whose singer Alexander Krull she married on 3 July 2003. With the five musicians from Atrocity she formed a new band, Leaves' Eyes, in August 2003. She has also released five solo albums, the most recent of which was released in October 2014 through Napalm Records.
Kristine has a soprano vocal range.
In 2005, Liv Kristine was nominated for a Grammy award with Cradle of Filth for the song "Nymphetamine".
In 2016, Liv joined Eluveitie as a session vocalist for a couple of their live shows after the departure of their singer Anna Murphy.
On 16 April 2016, Leaves' Eyes stated that Liv Kristine, who formed and had the idea of the band project, was no longer the singer of the band.
In December 2017 it was announced that Liv joins her sister Carmen's band Midnattsol. She was originally announced to be a guest on their new album but after some discussions, the band picked her up as a permanent member.