Kalmiopsis Wilderness is a wilderness area in the Klamath Mountains of southwestern Oregon, within the Rogue River – Siskiyou National Forest. It was designated wilderness by the United States Congress in 1964 and now comprises a total of 179,755 acres (72,744 ha). There are approximately 153 miles (246 km) of trails on 24 established hiking trails in the area.
The Kalmiopsis Wilderness was named for Kalmiopsis leachiana, a slow-growing plant related to the rhododendron, which was discovered in the area in 1930.
The wilderness area was established in 1964. In 2002, lightning started the Biscuit Fire that burned much of the area and damaged many of the hiking trails. Some of the trails destroyed in the fire re-opened in 2015.