Hondo was born in Aichi Prefecture on March 6, 1996. She had an interest in anime from a young age, in particular the Naruto series. She became interested in acting and modelling after an incident during her fifth year of elementary, when a woman came close to her saying she has "a face that goes well with makeup". Not knowing immediately what that should mean, she made some research on her own later, and came to believe she was told she has a face suitable for an actress or a model. She would then start auditioning for various acting and modelling jobs, but she did not initially consider voice acting as an option. As she had a desire to perform in front of people, upon entering high school, she joined her school's theater club.
While in high school, Hondo acted in school plays and also participated in activities such as swimming, basketball, soft tennis, and softball. While in her third year of school, one of her instructors was a radio personality, and her experiences with them and the club influenced her to decide to become a voice actor. In pursuit of this career, she enrolled at the Japan Narration Actor Institute. After completing her training, she became afiliated with the voice acting agency I'm Enterprise. She made her voice acting debut in 2015, playing minor roles in series such as Aoharu × Machinegun. Later that year, she was cast in her first main role as Kokoro Yotsuba, the protagonist of the anime series Kamisama Minarai: Himitsu no Cocotama.
In 2016, Hondo played the roles of Kazane Aoba in Keijo!!!!!!!! and Yae Kugayama in Girlish Number; she and the other main cast members of Girlish Number also performed the series' opening theme "Bloom" and ending theme "Ima wa Mijikashi Yumemiyo Otome" (今は短し夢見よ乙女). The following year, she played the roles of Hikari Takanashi in Interviews with Monster Girls, Kon Tatsumi in Urara Meirocho, and Minoa Asagaya in Anime-Gataris. In 2018, she played the roles of Kanami Etō in Katana Maidens ~ Toji No Miko, Koyume Koizuka in Comic Girls, Hitomi Mishima in Hinamatsuri, Kohaku Tsukishiro in Iroduku: The World in Colors, and Sakura Minamoto in Zombie Land Saga.