The senior line of the House of Bourbon became extinct in the male line in 1527 with the death of Charles III, Duke of Bourbon. This made the junior Bourbon-Vendome branch the genealogically senior branch of the House of Bourbon. In 1589, at the death of Henry III of France, the House of Valois became extinct in the male line. Under the Salic law, the Head of the House of Bourbon, as the senior representative of the senior-surviving branch of the Capetian dynasty, became King of France as Henry IV. Bourbon monarchs then united to France the small kingdom of Navarre, which Henry's father had acquired by marriage in 1555, ruling both until the 1792 overthrow of the monarchy during the French Revolution. Restored briefly in 1814 and definitively in 1815 after the fall of the First French Empire, the senior line of the Bourbons was finally overthrown in the July Revolution of 1830. A cadet Bourbon branch, the House of Orléans, then ruled for 18 years (1830–1848), until it too was overthrown.
The Princes de Condé were a cadet branch of the Bourbons descended from an uncle of Henry IV, and the Princes de Conti were a cadet line of the Condé branch. Both houses were prominent French noble families well known for their participation in French affairs, even during exile in the French Revolution, until their respective extinctions in 1830 and 1814.
In 1700, at the death of Charles II of Spain, the Spanish Habsburgs became extinct in the male line. Under the will of the childless Charles II, the second grandson of Louis XIV of France was named as his successor, to preclude the union of the thrones of France and Spain. The prince, then Duke of Anjou, became Philip V of Spain. Permanent separation of the French and Spanish thrones was secured when France and Spain ratified Philip's renunciation, for himself and his descendants, of the French throne in the Treaty of Utrecht in 1714, and similar arrangements later kept the Spanish throne separate from those of the Two Sicilies and Parma. The Spanish House of Bourbon (rendered in Spanish as Borbón[boɾˈβon]) has been overthrown and restored several times, reigning 1700–1808, 1813–1868, 1875–1931, and since 1975. Bourbons ruled in Naples from 1734 to 1806 and in Sicily from 1734 to 1816, and in a unified Kingdom of the Two Sicilies from 1816 to 1860. They also ruled in Parma from 1731 to 1735, 1748–1802 and 1847–1859.