John Dryden (1631–1700) lived for a while at 43 Gerrard Street, which is commemorated by a blue plaque. Another plaque, on number 9, marks the meeting of Samuel Johnson and Joshua Reynolds at the
Turk's Head Tavern to found The Club, a dining club, in 1764.
In fiction, Charles Dickens sets the home of Mr Jaggers, the lawyer in Great Expectations, in "a house on the south side of that street. Rather a stately house of its kind, but dolefully in want of painting, and with dirty windows [and with ...] a stone hall... a dark brown staircase ... dark brown rooms... panelled walls". A Royal Society of Arts blue plaque commemorates Edmund Burke at 37 Gerrard Street.
In 1953, No. 4 Gerrard Street was a small studio where the theatrical photographer George Harrison Marks and his partner Pamela Green, lived and worked. By the late 1950s, with the success of Kamera Publications, they had taken over No. 5 next door and had a much larger studio on the top floor. In the early 1960s the ground floor at No. 4 became a gallery. The director Michael Powell copied their sets for the classic film Peeping Tom, in which Green also starred.