Fatty liver disease

Fatty liver
SynonymsHepatic steatosis, simple fatty liver, simple steatosis
Non-alcoholic fatty liver disease1.jpg
Micrograph showing a fatty liver (macrovesicular steatosis), as seen in non-alcoholic fatty liver disease. Trichrome stain.
SpecialtyGastroenterology

Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in the liver.[1]

There are two types non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease.[1] NAFLD is made up of simple fatty liver and non-alcoholic steatohepatitis (NASH).[2] Risk factors for NAFLD include diabetes, obesity, and older age.[2]

The condition is also associated with other diseases that influence fat metabolism.[3] It is difficult to distinguish alcoholic FLD, which is part of alcoholic liver disease, from nonalcoholic FLD (NAFLD), and both show microvesicular and macrovesicular fatty changes at different stages.

Signs and symptoms

Complications

Fatty liver can develop into a fibrosis or a liver cancer.[4] For people affected by NAFLD, the 10-year survival rate was about 80%. The rate of progression of fibrosis in NASH is estimated to one per 7 years and 14 years for NAFLD, with an increasing speed.[5][6] There is a strong relationship between these pathologies and metabolic illnesses (diabetes type II, metabolic syndrome). These pathologies can also affect non-obese people, who are then at a higher risk.[4]

Less than 10% of people with cirrhotic alcoholic FLD will develop hepatocellular carcinoma,[7] the liver cancer, but up to 45% people with NASH without cirrhosis can develop hepatocellular carcinoma.[8]

Other Languages
العربية: كبد دهني
čeština: Steatóza jater
Deutsch: Fettleber
فارسی: کبد چرب
한국어: 지방간
Nederlands: Leververvetting
日本語: 脂肪肝
norsk: Steatose
português: Fígado gorduroso
suomi: Rasvamaksa
svenska: Fettlever
Tiếng Việt: Gan nhiễm mỡ
中文: 脂肪肝