|Endometriosis as seen during |
|Usual onset||30–40 years old|
|Based on symptoms, |
|Frequency||10.8 million (2015)|
Endometriosis is a condition in which
The cause is not entirely clear. Risk factors include having a family history of the condition. The areas of endometriosis bleed each month, resulting in inflammation and scarring. The growths due to endometriosis are not
Tentative evidence suggests that the use of
One estimate is that 10.8 million people are affected globally as of 2015. Other sources estimate about 6–10% of women are affected. Endometriosis is most common in those in their thirties and forties; however, it can begin in girls as early as eight years old. It results in few deaths. Endometriosis was first determined to be a separate condition in the 1920s. Before that time, endometriosis and
Pain and infertility are common symptoms, although 20-25% of women are asymptomatic.
A major symptom of endometriosis is recurring
Compared with women with superficial endometriosis, those with deep disease appear to be more likely to report shooting rectal pain and a sense of their insides being pulled down. Individual pain areas and pain intensity appear to be unrelated to the surgical diagnosis, and the area of pain unrelated to area of endometriosis.
There are multiple causes of pain. Endometriosis lesions react to hormonal stimulation and may "bleed" at the time of menstruation. The blood accumulates locally if it is not cleared shortly by the immune, circulatory, and lymphatic system. This may further lead to swelling, which triggers inflammation with the activation of
Also, endometriotic lesions can develop their own nerve supply, thereby creating a direct and two-way interaction between lesions and the
About a third of women with
There is an association between endometriosis and certain types of cancers, notably some types of
Rarely, endometriosis can cause endometrial tissue to be found in other parts of the body.