A variety of Christianities developed throughout the 2nd and 3rd century, alongside a developing proto-orthodoxy, which eventually defined orthodoxy and heresy. Proto-orthodoxy developed in tandem with the growing number of Christians, which necessitated the development of ecclesiastical structure.
Early Jewish Christians referred to themselves as 'The Way' (Isaiah 40:3, "prepare the way of the Lord."[web 1][note 2] According to Acts 11:26, the term "Christian" (Greek: Χριστιανός) was first used in reference to Jesus's disciples in the city of Antioch, meaning "followers of Christ," by the non-Jewish inhabitants of Antioch. The earliest recorded use of the term "Christianity" (Greek: Χριστιανισμός) was by Ignatius of Antioch, in around 100 AD.