It has a wide cultural tradition that comes from being the urban settlement founded by the Spanish conquerors who colonized the interior of the continent. It was the first capital of the Venezuela Province and head of the first bishop founded in South America in 1531. As Neu-Augsburg, it was the first German colony in the Americas under the Welsers. The precursor movement of the independence and of vindication of the dominated classes in Venezuela originated in this region; it is also considered to be the cradle of the Venezuelan federalist movement in the Republican era.
Thanks to the city's history, culture and its well-preserved Colonial architecture,"Coro and its port La Vela" was designated in 1993 as a World Heritage Site by UNESCO, thus becoming the first site in Venezuela to be vested with this title. Since 2005 it is on the UNESCO's List of World Heritage in Danger.
At its founding the town was called Santa Ana de Coro (there is now an unsuccessful campaign to redeem the colonial name of the city) in the Spanish style that named new cities in America according to the Catholic calendar, accompanied by a name of Indian origin. According to the tradition the word coro derives from the Caquetio word curiana, meaning "place of winds". However, according to the authoritative DRAE Spanish dictionary, the word coro in its second meaning means "wind of the northwest", and comes from the Latin caurus.