Essen, the son of architect
Horst Loy and a translator, Loy began studies of opera directing at the
Folkwangschule with Dieter Bülter-Marell at the age of 14. He received the Folkwang-Preis award for his first staged work,
 He studied in Essen until 1982 and continued his studies at the
Munich University, including science of the theatre, art history, and Italian studies.
 In 1984, Loy began work as an assistant at the
Musiktheater im Revier, where he collaborated with
Dietrich Hilsdorf and
Jaroslav Chundela , among others. In 1986, he moved to the
Staatstheater Wiesbaden, and since 1990 he has worked as a freelance director.
He made his debut at the
Royal Opera House in 2002 with
Ariadne auf Naxos, conducted by
Antonio Pappano who was then the new music director. He also staged there Donizetti's
Lucia di Lammermoor, Alban Berg's
Lulu and Wagner's
Tristan und Isolde.
 He directed Mussorgski's
Khovanshchina at the Dutch National Opera, Handel's
Alcina and Bellini's
I Capuleti e i Montecchi at the
Opernhaus Zürich, Verdi's
Macbeth at the
Grand Théâtre de Genève, Britten's
Peter Grimes at the
Theater an der Wien, Janáček's
Jenůfa at the
Deutsche Oper Berlin,
Der Rosenkavalier by Richard Strauss at the
Royal Swedish Opera, Mozart's
Così fan tutte
Arabella by Richard Strauss at the
Frankfurt Opera, his
Daphne at the
Theater Basel, and Handel's
Theodora for the
 In 2017, he directed the premiere of
Andrea Lorenzo Scartazzini's Edward II. at the Deutsche Oper Berlin.
Among other awards, his staging of Mozart's
Così fan tutte at the Frankfurt Opera earned him the prize
Der Faust in the category direction in music theatre (Regie Musiktheater) in 2008.