Manchester City claimed the league title on the final day of the season with a 4–1 win at Brighton & Hove Albion, finishing on 98 points after a run of 14 wins. Liverpool held a 7 point lead over Manchester City on 3 January, but finished runners-up with 97 points – the third highest total in Premier League history and the highest in English top-flight history for a second-placed team, having lost only one league match all season – to eventual champions City.
Chelsea and Tottenham Hotspur claimed the other two Champions League berths, finishing in third and fourth place respectively. Tottenham were in third place for much of the season and were considered potential title challengers until a 1–2 loss to Burnley in February. Arsenal went on a fourteen-game unbeaten run near the start of the season and began April in third place, but a run of four points in six matches saw them drop to fifth place, finishing outside of the Champions League places. Manchester United's worst start to the season for 28 years led to the sacking of manager José Mourinho in December, with former player Ole Gunnar Solskjær replacing him, initially as a caretaker. Solskjær was appointed permanently after an impressive run of results which culminated in United's away goals victory over Paris Saint-Germain in the UEFA Champions League, but the team's poor form soon returned and they eventually finished sixth after winning none of their final five league matches. Newly promoted Wolverhampton Wanderers achieved their highest finish since 1980 by finishing seventh, having taken points off every team in the league except Liverpool and Huddersfield Town.
Huddersfield were the first team to be relegated, following their 0–2 defeat at Crystal Palace on 30 March 2019, coinciding with victories for Burnley and Southampton. They were relegated with six games remaining. This made Huddersfield the second team to be relegated before March ended, following Derby County in 2007–08. Fulham joined them after a 1–4 defeat at Watford on 2 April, relegated with five games remaining. Cardiff City were the final team to be relegated following a 2–3 loss at home to Crystal Palace on 4 May with one game remaining.
The fastest goal in Premier League history was scored this season on 23 April by Shane Long in a 1–1 draw between his side Southampton and Watford after 7.69 seconds. On 4 May 2019, Fulham's Harvey Elliott became the youngest ever Premier League player at 16 years and 30 days. Tottenham Hotspur had a run of 28 games without a draw, the longest ever recorded in a single Premier League season.
The season saw the occurrence of two aviation incidents involving Premier League personnel. On 27 October 2018, Leicester City owner Vichai Srivaddhanaprabha was killed in a helicopter crash outside the King Power Stadium, shortly after a 1–1 home draw against West Ham United. Almost three months later, on 21 January 2019, Cardiff City player Emiliano Sala, en route to join the club following his record signing from Nantes, died on board a Piper PA-46 Malibu aircraft that crashed off Alderney.